2000s–present

In 2002, Clorox entered into a joint venture with Procter & Gamble to create food and trash bags, food wraps, and containers under the names Glad, GladWare and related trademarks. As part of this agreement, Clorox sold a 10% stake in the Glad products to P&G, which increased to 20% in 2005.

In 2007, the company acquired Burt's Bees. In 2010, Clorox shed businesses that were no longer a good strategic fit for the company, announcing that it was selling the Armor All and STP brands to Avista Capital Partners. In 2011, Clorox acquired the Aplicare and HealthLink brands, bolstering its presence in the healthcare industry.

In 2008, The Clorox Company became the first major consumer packaged goods company to develop and nationally launch a green cleaning line, Green Works, into the mainstream cleaning aisle. In 2011, the Clorox Company integrated corporate social responsibility (CSR) reporting with financial reporting. The company's annual report for the fiscal year ending in June 2011 shared data on financial performance as well as advances in environmental, social and governance performance.

In 2013 the company announced a focus on consumer mega trends that included sustainability, health and wellness, affordability/value, and multiculturalism, with a particular focus on the Hispanic community.

In 2015, the company became a signatory of the United Nations Global Compact, a large corporate responsibility initiative.

In 2018 Clorox purchased Nutranext Business, LLC for approximately $700 million. Florida-based Nutranext makes natural multivitamins, specialty minerals used as health aids, and supplements for hair, skin and nails. Operating income in 2018 was US$1.1 billion. With approximately 8,700 employees worldwide as of 2018, yearly revenue for the period ending June 30, 2018, equaled $6.1 billion. Yearly revenue equaled $6.2 in 2019.In 2019, Clorox ranked 7th in Barron's "100 Most Sustainable U.S. Companies" list.